Conclusion: This monocenter study demonstrates that control of life-threatening bleeding, eradication of the inhibitor, and induction of tolerance to endogenous FVIII have significantly improved the clinical outcome of acquired haemophilia A. Our data also suggest a shift in underlying disorders associated with acquired haemophilia A, whereby, in comparison to published studies, a relative increase in [...]

Authors: Smojver-Jezek S, Peros-Golubicić T, Tekavec-Trkanjec J, Alilović M, Vrabec-Branica B, Juros Z, Mazuranić I
Lymphocytic alveolitis is a characteristic of diverse interstitial lung diseases (ILD-s), but macrophages are often more numerous cell population in bronchoalveolar lavage fluid (BALF). Aim of this study is to analyze morphometric characteristics of macrophages nuclei in [...]

Conclusion
Differences in aetiology of GG between children and adults reflect age-specific disease states. Gender differences can be partially explained by gender differences intrinsic to the underlying aetiology. Irrespective of the underlying aetiology, the number and location of granulomas are similar in children and adults. (Source: Journal of Clinical Pathology)

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In this study, we investigate the interaction between monocyte-derived dendritic cells and T cells in patients with sarcoidosis compared to normal controls (n = 8 each) by examining the kinetics of autologous and allogeneic mixed leucocyte reactions over 9-10 days. We found markedly depressed proliferation kinetics in autologous DC-peripheral blood mononuclear cell (PBMC) co-cultures from [...]

In this study, we investigate the interaction between monocyte-derived dendritic cells and T cells in patients with sarcoidosis compared to normal controls (n = 8 each) by examining the kinetics of autologous and allogeneic mixed leucocyte reactions over 9[ndash]10 days. We found markedly depressed proliferation kinetics in autologous DC-peripheral blood mononuclear cell (PBMC) co-cultures from [...]

CONCLUSIONS: Our results propose that the respective regions might harbor r yet unidentified, possibly subphenotype-specific risk factors for the disease, e.g. with immune-related functions like the tumor necrosis factor receptor 1. They should be proved to be important for SA pathogenesis and investigated in detail with an emphasis on rare variants. Subphenotype-specific risk factors might [...]

CONCLUSIONS: The findings suggest that patients with progressive/fibrotic pulmonary sarcoidosis have intense immune activity related to host defence, in their lungs; with processes more similar to HP than IPF. The study also demonstrates that transbronchial lung biopsy samples can provide good quality RNA for gene expression profiling, supporting its potential use as a prognostic classifier [...]

Conclusion  The diagnostic performance of HRCT is high and can be increased by adding clinical data.
Content Type Journal ArticleCategory ChestDOI 10.1007/s00330-009-1671-4Authors
Sophie Grivaud Martin, Université Paris 13, Assistance Publique–Hôpitaux de Paris, Hôpital Avicenne UPRES EA 2363, Department of Radiology 125, route de stalingrad 93000 Bobigny FranceLouis-Philippe Kronek, Université Joseph Fourier Laboratoire G-SCOP 46 avenue Felix Viallet 38031 [...]

In this study, we genotyped 6 SNPs using SNaPshot in 286 tuberculosis cases and 608 controls in Chinese. Our genetic study revealed a significant association between the rs3763313, rs9268494, rs9268492 SNPs in the BTNL2 gene and tuberculosis. And haplotype 1,2,3,4,5, 8 (C-A-G-T-G-A, C-A-G-T-G-G, C-A-T-G-C-A, C-A-T-G-C-G, C-G-T-G-C-G, T-A-T-G-C-A) were present a significant association with susceptibility to [...]

Mayock RL, Bertrand P, Morrison CE, Scott JH (Source: The Aspergillus Website – articles)

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Source: MedWorm: Sarcoidosis