M[Phi] and DC are key elements in the control of tissue homeostasis and response to insult. In this work, we demonstrate that M[Phi] and DC are the major producers of the phenylalanine catabolizing enzyme IL-4-induced gene 1 (IL4I1) under inflammatory conditions. IL4I1 was first described in B cells, which indeed can produce IL4I1 in vitro, [...]

In this study, we genotyped 6 SNPs using SNaPshot in 286 tuberculosis cases and 608 controls in Chinese. Our genetic study revealed a significant association between the rs3763313, rs9268494, rs9268492 SNPs in the BTNL2 gene and tuberculosis. And haplotype 1,2,3,4,5, 8 (C-A-G-T-G-A, C-A-G-T-G-G, C-A-T-G-C-A, C-A-T-G-C-G, C-G-T-G-C-G, T-A-T-G-C-A) were present a significant association with susceptibility to [...]

Conclusions. Our data suggest that increased expression of Flt-1 and downregulation of CXCL12α in IPF may further support the hypothesis of a different angiogenetic profile between fibrotic and granulomatous diseases. However, further studies are needed in order to better investigate these enigmatic diseases. (Source: Clinical and Developmental Immunology) MedWorm Message: Get the very latest Swine [...]