Semin Respir Crit Care Med 2010; 31: 474-484DOI: 10.1055/s-0030-1262215ABSTRACTThe synthesis of vitamin D is altered by the granulomatous inflammation of sarcoidosis leading to increased production of 1, 25-dihydroxyvitamin D. Mounting evidence suggests that vitamin D is an immunomodulating hormone that inhibits both antigen presentation by cells of the innate immune system, and the cytokine release [...]