[Large-vessel granulomatous vasculitis during the course of sarcoidosis: Takayasu's arteritis?]
We report the case of a man with a 10-year history of cutaneous and pulmonary sarcoidosis who developed ischaemia of the right upper limb evocative of Takayasu’s arteritis. The patient was successfully treated with oral steroids and methotrexate. DISCUSSION: This case prompts discussion about the relationship between Takayasu’s disease and sarcoidosis. Physicians should be aware [...]
The role of tumor necrosis factor alpha G-308A polymorphisms in the course of pulmonary sarcoidosis
This study was designed to evaluate the relationship between the presence of tumor necrosis factor (TNF) polymorphisms, human leukocyte antigen (HLA)-DRB1*03 linkage and the prognosis of sarcoidosis. In a retrospective case[ndash]control study, TNF-[alpha]G-308A, TNF-[alpha]G-238A, lymphotoxin-[alpha] (LTA) and HLA-DRB1*03 were genotyped in 625 sarcoidosis patients. These patients were classified into 298 patients with persistent disease and [...]