Hepatocyte growth factor in exhaled breath and BAL fluid in sarcoidosis.
Conclusions: HGF is detectable in BAL and EBC. However, it does not distinguish sarcoidosis patients from healthy subjects. The above, as well as the lack of correlations with various parameters of disease activity and severity rule out EBC/ /BALF HGF as a biomarker for sarcoidosis monitoring. PMID: 20461686 [PubMed - in process] (Source: Pneumonologia i [...]
The role of tumor necrosis factor alpha G-308A polymorphisms in the course of pulmonary sarcoidosis
This study was designed to evaluate the relationship between the presence of tumor necrosis factor (TNF) polymorphisms, human leukocyte antigen (HLA)-DRB1*03 linkage and the prognosis of sarcoidosis. In a retrospective case[ndash]control study, TNF-[alpha]G-308A, TNF-[alpha]G-238A, lymphotoxin-[alpha] (LTA) and HLA-DRB1*03 were genotyped in 625 sarcoidosis patients. These patients were classified into 298 patients with persistent disease and [...]