Abstract  In 2001, a 41-year-old Japanese woman was referred to our hospital because of severe renal dysfunction and fever of unknown
origin. On admission, her serum creatinine was 8.7 mg/dL, urine protein was 0.3 g/day, and urine β2-microglobulin was 81,007 Î¼g/day. Computed tomography (CT) scans showed bilateral contracted kidneys with a mass projecting
from the lower pole of the [...]

In conclusion, BALF MRP14 levels are elevated in IPF and sarcoidosis and are associated with disease severity in sarcoidosis. The results support the need for further studies into the role of MRP14 in the pathogenesis of lung fibrosis. (Source: Clinical and Experimental Immunology)

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Authors: Smojver-Jezek S, Peros-Golubicić T, Tekavec-Trkanjec J, Alilović M, Vrabec-Branica B, Juros Z, Mazuranić I
Lymphocytic alveolitis is a characteristic of diverse interstitial lung diseases (ILD-s), but macrophages are often more numerous cell population in bronchoalveolar lavage fluid (BALF). Aim of this study is to analyze morphometric characteristics of macrophages nuclei in [...]

This article aims to increase the reader’s understanding of the aetiology of ILD and to provide a general approach to diagnosis along with the basic principles of management of these conditions. DISCUSSION: As ILDs can progress to pulmonary fibrosis, early detection is important. The clinical course of ILD varies considerably, largely determined by the underlying [...]

In conclusion, NAC inhibits production of factors playing a key role in the etiopathogenesis of interstitial lung diseases, thus suggesting its possible therapeutic potency in the treatment of these disorders.
PMID: 20360623 [PubMed - in process] (Source: Pharmacological Reports) Source: MedWorm: Sarcoidosis

In conclusion, it cannot be claimed that transbronchial biopsy is more useful in confirming usual interstitial pneumonia than previously recognized. The primary and main role of transbronchial biopsy in diagnosis of usual interstitial pneumonia is thought not to confirm a diagnosis, but to exclude other infiltrative diseases, such as malignancy, sarcoidosis or infections. (Source: Pathology [...]

We report a case and review the literature.
PMID: 19863887 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)

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Source: MedWorm: Sarcoidosis

Authors: Valeyre D, Freynet O, Dion G, Bouvry D, Annesi-Maesano I, Nunes H
Diffuse interstitial lung diseases (DILD) cover more than 200 conditions classified in 4 groups: secondary DILD; sarcoidosis; particular DILDs and idiopathic interstitial pneumonias. Overall, these diseases have a prevalence of 60-80/100 000 and an incidence around 30/100 000. Sarcoidosis [...]

Conclusion  The diagnostic performance of HRCT is high and can be increased by adding clinical data.
Content Type Journal ArticleCategory ChestDOI 10.1007/s00330-009-1671-4Authors
Sophie Grivaud Martin, Université Paris 13, Assistance Publique–Hôpitaux de Paris, Hôpital Avicenne UPRES EA 2363, Department of Radiology 125, route de stalingrad 93000 Bobigny FranceLouis-Philippe Kronek, Université Joseph Fourier Laboratoire G-SCOP 46 avenue Felix Viallet 38031 [...]

Authors: Heron M, Claessen AM, Grutters JC, van den Bosch JM
Summary Lymphocytes play a crucial role in lung inflammation. Different interstitial lung diseases may show distinct lymphocyte activation profiles. The aim of this study was to examine the expression of a variety of activation markers on T lymphocyte subsets from blood [...]