Semin Respir Crit Care Med 2010; 31: 380-389DOI: 10.1055/s-0030-1262206ABSTRACTSarcoidosis develops in genetically predisposed individuals that are exposed to unknown antigens. There is a statistically significant increased risk for the disease among family members of sarcoidosis patients, and the disease differs in different ethnic groups. It is a genetically complex disease, with many genes contributing, both [...]

Semin Respir Crit Care Med 2010; 31: 375-379DOI: 10.1055/s-0030-1262205ABSTRACTSarcoidosis is a disease of unknown etiology, characterized pathologically by noncaseating granulomas that most commonly involve the lung, skin, lymph nodes, and eyes. Syndromes with similar pathological and immunologic features to sarcoidosis such as chronic beryllium disease, hypersensitivity pneumonitis, and tuberculosis illustrate that granulomatous diseases may or [...]

(Source: Allergy and Asthma Proceedings) MedWorm Message: Register for MedMatcha, MedWorm’s medical advertising network, and receive $5 free advertising. Source: MedWorm: Sarcoidosis

Conclusions EBUS guided TBNA, in our experience, is a reliable technique for staging of lung cancers, and investigation of unexplained mediastinal lymphadenopathy and masses. LBC reduces the number of slides from 7.5 per case to 1 slide, reducing time required for diagnosis. (Source: Journal of Clinical Pathology) MedWorm Message: Get the very latest Swine Flu [...]

Authors: Domiciano DS, Carvalho JF, Shoenfeld Y Anti-endothelial cells antibodies have been detected in numerous autoimmune and inflammatory diseases, including systemic lupus erythematous, rheumatoid arthritis, vasculitis and sarcoidosis. Anti-endothelial cells antibodies bind to endothelial cell antigens and induce endothelial damage. Their effects on the endothelial cell have been considered responsible, at least in part, by [...]

Wonder Drake, MD, Assistant Professor of Medicine, Division of Infectious Diseases, Vanderbilt University, Nashville, Tennessee, teaches us about sarcoidosis.

Authors: Heron M, Claessen AM, Grutters JC, van den Bosch JM Summary Lymphocytes play a crucial role in lung inflammation. Different interstitial lung diseases may show distinct lymphocyte activation profiles. The aim of this study was to examine the expression of a variety of activation markers on T lymphocyte subsets from blood and bronchoalveolar lavage [...]

Lymphocytes play a crucial role in lung inflammation. Different interstitial lung diseases may show distinct lymphocyte activation profiles. The aim of this study was to examine the expression of a variety of activation markers on T lymphocyte subsets from blood and bronchoalveolar lavage fluid (BALF) of patients with different granulomatous interstitial lung diseases and healthy [...]

This study was designed to evaluate the relationship between the presence of tumor necrosis factor (TNF) polymorphisms, human leukocyte antigen (HLA)-DRB1*03 linkage and the prognosis of sarcoidosis. In a retrospective case[ndash]control study, TNF-[alpha]G-308A, TNF-[alpha]G-238A, lymphotoxin-[alpha] (LTA) and HLA-DRB1*03 were genotyped in 625 sarcoidosis patients. These patients were classified into 298 patients with persistent disease and [...]

Sarcoidosis-associated Pulmonary Hypertension: A Role for Endothelin Receptor …MedscapeData on the treatment of sarcoidosis-associated pulmonary hypertension are scarce, while the variety of underlying pathophysiologic mechanisms are a major … Source: sarcoidosis – Google News