Authors: Koiwa H, Tsujino I, Ohira H, Yoshinaga K, Otsuka N, Nishimura M PMID: 20679583 [PubMed - in process] (Source: Circulation) Source: MedWorm: Sarcoidosis Stop Suffering the Living Hell of Sarcoidosis With Natural Alternatives and Without Drugs or Surgery

Authors: Swaisgood CM, Oswald-Richter K, Moeller SD, Klemenc JM, Ruple LM, Farver CF, Drake JM, Culver DA, Drake WP Sarcoidosis is characterized by noncaseating granulomas containing CD4+ T cells with a Th1 immunophenotype. While the causative antigen(s) is not known, independent studies have noted molecular and immunologic evidence of mycobacterial virulence factors in sarcoidosis specimens. [...]

CONCLUSIONS: Our results propose that the respective regions might harbor r yet unidentified, possibly subphenotype-specific risk factors for the disease, e.g. with immune-related functions like the tumor necrosis factor receptor 1. They should be proved to be important for SA pathogenesis and investigated in detail with an emphasis on rare variants. Subphenotype-specific risk factors might [...]